The AID dilemma: infection, or cancer?
T Honjo, M Kobayashi, N Begum, A Kotani… - Advances in cancer …, 2012 - Elsevier
Activation-induced cytidine deaminase (AID), which is both essential and sufficient for
forming antibody memory, is also linked to tumorigenesis. AID is found in many B
lymphomas, in myeloid leukemia, and in pathogen-induced tumors such as adult T cell
leukemia. Although there is no solid evidence that AID causes human tumors, AID-
transgenic and AID-deficient mouse models indicate that AID is both sufficient and required
for tumorigenesis. Recently, AID's ability to cleave DNA has been shown to depend on …
forming antibody memory, is also linked to tumorigenesis. AID is found in many B
lymphomas, in myeloid leukemia, and in pathogen-induced tumors such as adult T cell
leukemia. Although there is no solid evidence that AID causes human tumors, AID-
transgenic and AID-deficient mouse models indicate that AID is both sufficient and required
for tumorigenesis. Recently, AID's ability to cleave DNA has been shown to depend on …