A role for p53 in the frequency and mechanism of mutation
SM Morris - Mutation Research/Reviews in Mutation Research, 2002 - Elsevier
The tumor suppressor protein, p53, is often referred to as the guardian of the genome. When
p53 function is impaired, its ability to preserve genomic integrity is compromised. This may
result in an increase in mutation on both a molecular and chromosomal level and contribute
to the progression to a malignant phenotype. In order to study the effect of p53 function on
the acquisition of mutation, in vitro and in vivo models have been developed in which both
the frequency and mechanism of mutation can be analyzed. In human lymphoblastoid cells …
p53 function is impaired, its ability to preserve genomic integrity is compromised. This may
result in an increase in mutation on both a molecular and chromosomal level and contribute
to the progression to a malignant phenotype. In order to study the effect of p53 function on
the acquisition of mutation, in vitro and in vivo models have been developed in which both
the frequency and mechanism of mutation can be analyzed. In human lymphoblastoid cells …