The INK4A/ARF locus and its two gene products
NE Sharpless, RA DePinho - Current opinion in genetics & development, 1999 - Elsevier
Current opinion in genetics & development, 1999•Elsevier
The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in
human cancer. Two genes comprising overlapping reading frames encoding p16INK4a and
p19ARF have been discovered at this locus and, remarkably, both play an important role in
regulating cell growth, survival and senescence.
human cancer. Two genes comprising overlapping reading frames encoding p16INK4a and
p19ARF have been discovered at this locus and, remarkably, both play an important role in
regulating cell growth, survival and senescence.
The INK4A/ARF locus on chromosome 9 is one of the sites mutated most frequently in human cancer. Two genes comprising overlapping reading frames encoding p16INK4a and p19ARF have been discovered at this locus and, remarkably, both play an important role in regulating cell growth, survival and senescence.
Elsevier