Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming

J Wolfers, A Lozier, G Raposo, A Regnault, C Théry… - Nature medicine, 2001 - nature.com
J Wolfers, A Lozier, G Raposo, A Regnault, C Théry, C Masurier, C Flament, S Pouzieux…
Nature medicine, 2001nature.com
The initiation of T-cell–mediated antitumor immune responses requires the uptake and
processing of tumor antigens by dendritic cells and their presentation on MHC-I molecules.
Here we show in a human in vitro model system that exosomes, a population of small
membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to
dendritic cells. After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell–
dependent antitumor effects on syngeneic and allogeneic established mouse tumors …
Abstract
The initiation of T-cell–mediated antitumor immune responses requires the uptake and processing of tumor antigens by dendritic cells and their presentation on MHC-I molecules. Here we show in a human in vitro model system that exosomes, a population of small membrane vesicles secreted by living tumor cells, contain and transfer tumor antigens to dendritic cells. After mouse tumor exosome uptake, dendritic cells induce potent CD8+ T-cell–dependent antitumor effects on syngeneic and allogeneic established mouse tumors. Therefore, exosomes represent a novel source of tumor-rejection antigens for T-cell cross priming, relevant for immunointerventions.
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