Metastasis is a complex clinical and biological problem presently under intense study, and
several model systems are in use to experimentally recapitulate and dissect the various
steps of the metastatic process. Genetically engineered mouse models provide faithful
renditions of events in tumor progression, angiogenesis, and local invasion that set the
stage for metastasis, whereas engrafting of human or mouse tumor tissues into mouse hosts
has been successfully exploited to investigate metastatic dissemination and colonization of …