[HTML][HTML] The chemokine CCL5 regulates glucose uptake and AMP kinase signaling in activated T cells to facilitate chemotaxis
O Chan, JD Burke, DF Gao, EN Fish - Journal of Biological Chemistry, 2012 - ASBMB
Recruitment of effector T cells to sites of infection or inflammation is essential for an effective
adaptive immune response. The chemokine CCL5 (RANTES) activates its cognate receptor,
CCR5, to initiate cellular functions, including chemotaxis. In earlier studies, we reported that
CCL5-induced CCR5 signaling activates the mTOR/4E-BP1 pathway to directly modulate
mRNA translation. Specifically, CCL5-mediated mTOR activation contributes to T cell
chemotaxis by initiating the synthesis of chemotaxis-related proteins. Up-regulation of …
adaptive immune response. The chemokine CCL5 (RANTES) activates its cognate receptor,
CCR5, to initiate cellular functions, including chemotaxis. In earlier studies, we reported that
CCL5-induced CCR5 signaling activates the mTOR/4E-BP1 pathway to directly modulate
mRNA translation. Specifically, CCL5-mediated mTOR activation contributes to T cell
chemotaxis by initiating the synthesis of chemotaxis-related proteins. Up-regulation of …