[HTML][HTML] Alkyl phospholipid perifosine induces myeloid hyperplasia in a murine myeloma model
L Catley, T Hideshima, D Chauhan, P Neri… - Experimental …, 2007 - Elsevier
OBJECTIVES: Alkyl-lysophospholipids are a novel class of antitumor agents. Perifosine is a
novel alkyl-lysophospholipid that can induce apoptosis in multiple myeloma (MM) tumor
cells, both in vitro and in vivo. We investigated the effects of perifosine on the peripheral
blood, bone marrow, and spleen of mice inoculated with subcutaneous plasmacytomas.
METHODS: Immunocompromised mice were inoculated with myeloma cell lines and treated
with oral perifosine in either a daily or weekly schedule, or with vehicle only. When …
novel alkyl-lysophospholipid that can induce apoptosis in multiple myeloma (MM) tumor
cells, both in vitro and in vivo. We investigated the effects of perifosine on the peripheral
blood, bone marrow, and spleen of mice inoculated with subcutaneous plasmacytomas.
METHODS: Immunocompromised mice were inoculated with myeloma cell lines and treated
with oral perifosine in either a daily or weekly schedule, or with vehicle only. When …