[HTML][HTML] Disabled-2 (Dab2) is required for transforming growth factor β-induced epithelial to mesenchymal transition (EMT)
C Prunier, PH Howe - Journal of Biological Chemistry, 2005 - ASBMB
Transforming growth factor β (TGFβ) induces an epithelial to mesenchymal transition (EMT)
during both physiological and pathological processes; however, the mechanism underlying
this transition is not fully elucidated. Here, we have demonstrated that TGFβ induces the
expression of the adaptor molecule disabled-2 (Dab2) concomitant with the promotion of
EMT. We show that TGFβ induces a transient accumulation of Dab2 to the membrane and
increases Dab2 binding to β1 integrin. Furthermore, small interfering RNA (siRNA)-mediated …
during both physiological and pathological processes; however, the mechanism underlying
this transition is not fully elucidated. Here, we have demonstrated that TGFβ induces the
expression of the adaptor molecule disabled-2 (Dab2) concomitant with the promotion of
EMT. We show that TGFβ induces a transient accumulation of Dab2 to the membrane and
increases Dab2 binding to β1 integrin. Furthermore, small interfering RNA (siRNA)-mediated …