Immature dendritic cell exosomes suppress experimental autoimmune myasthenia gravis

N Bu, HQ Wu, GL Zhang, SQ Zhan, R Zhang… - Journal of …, 2015 - Elsevier
Immature dendritic cell-derived exosomes (iMDEX) display a certain degree of
immunosuppressive activity in autoimmune diseases. However, the role of iMDEX in
experimental autoimmune myasthenia gravis (EAMG) is still unclear. Therefore, we tested
the effects of mouse bone marrow (BM)-derived iMDEX on tolerance induction in a mouse
model of EAMG. In this study, we found that the CELLine culture system produced more
exosomes, the morphology and phenotype of these exosomes were found to be identical …