[HTML][HTML] Particle size distribution of exosomes and microvesicles determined by transmission electron microscopy, flow cytometry, nanoparticle tracking analysis, and …
E Van der Pol, FAW Coumans, AE Grootemaat… - Journal of Thrombosis …, 2014 - Elsevier
Background Enumeration of extracellular vesicles has clinical potential as a biomarker for
disease. In biological samples, the smallest and largest vesicles typically differ 25‐fold in
size, 300 000‐fold in concentration, 20 000‐fold in volume, and 10 000 000‐fold in scattered
light. Because of this heterogeneity, the currently employed techniques detect
concentrations ranging from 10 4 to 10 12 vesicles mL–1. Objectives To investigate whether
the large variation in the detected concentration of vesicles is caused by the minimum …
disease. In biological samples, the smallest and largest vesicles typically differ 25‐fold in
size, 300 000‐fold in concentration, 20 000‐fold in volume, and 10 000 000‐fold in scattered
light. Because of this heterogeneity, the currently employed techniques detect
concentrations ranging from 10 4 to 10 12 vesicles mL–1. Objectives To investigate whether
the large variation in the detected concentration of vesicles is caused by the minimum …