[HTML][HTML] Neutral sphingomyelinase 2 (nSMase2)-dependent exosomal transfer of angiogenic microRNAs regulate cancer cell metastasis

N Kosaka, H Iguchi, K Hagiwara, Y Yoshioka… - Journal of Biological …, 2013 - ASBMB
The release of humoral factors between cancer cells and the microenvironmental cells is
critical for metastasis; however, the roles of secreted miRNAs in non-cell autonomous
cancer progression against microenvironmental cells remain largely unknown. Here, we
demonstrate that the neutral sphyngomyelinase 2 (nSMase2) regulates exosomal microRNA
(miRNA) secretion and promotes angiogenesis within the tumor microenvironment as well
as metastasis. We demonstrate a requirement for nSMase2-mediated cancer cell exosomal …