[PDF][PDF] A specific chemical difference between the globins of normal human and sickle-cell anaemia haemoglobin
VM Ingram - Nature, 1956 - samblackman.org
NEW and rapid technique of characterizing the chemical properties of a protein in
considerable detail has been devised; by its application a specific difference is found in the
sequence of amino-acid residues of normal and sickle-cell hæmoglobin. This difference
appears to be confined to one small section of one of the polypeptide chains. Of all the
abnormal human hæmoglobins, the one that has been most intensively studied is
hæmoglobin S from patients with sickle-cell anæmia. In 1949 Pauling and his collaborators" …
considerable detail has been devised; by its application a specific difference is found in the
sequence of amino-acid residues of normal and sickle-cell hæmoglobin. This difference
appears to be confined to one small section of one of the polypeptide chains. Of all the
abnormal human hæmoglobins, the one that has been most intensively studied is
hæmoglobin S from patients with sickle-cell anæmia. In 1949 Pauling and his collaborators" …