[HTML][HTML] Mitogen activated protein kinase family proteins and c-jun signaling in injury-induced Schwann cell plasticity

HJ Lee, YK Shin, HT Park - Experimental neurobiology, 2014 - ncbi.nlm.nih.gov
HJ Lee, YK Shin, HT Park
Experimental neurobiology, 2014ncbi.nlm.nih.gov
Schwann cells (SCs) in the peripheral nerves myelinate axons during postnatal
development to allow saltatory conduction of nerve impulses. Well-organized structures of
myelin sheathes are maintained throughout life unless nerves are insulted. After peripheral
nerve injury, unidentified signals from injured nerves drive SC dedifferentiation into an
immature state. Dedifferentiated SCs participate in axonal regeneration by producing
neurotrophic factors and removing degenerating nerve debris. In this review, we focus on …
Abstract
Schwann cells (SCs) in the peripheral nerves myelinate axons during postnatal development to allow saltatory conduction of nerve impulses. Well-organized structures of myelin sheathes are maintained throughout life unless nerves are insulted. After peripheral nerve injury, unidentified signals from injured nerves drive SC dedifferentiation into an immature state. Dedifferentiated SCs participate in axonal regeneration by producing neurotrophic factors and removing degenerating nerve debris. In this review, we focus on the role of mitogen activated protein kinase family proteins (MAP kinases) in SC dedifferentiation. In addition, we will highlight neuregulin 1 and the transcription factor c-jun as upstream and downstream signals for MAP kinases in SC responses to nerve injury.
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