Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses

S Hugues, A Scholer, A Boissonnas, A Nussbaum… - Nature …, 2007 - nature.com
S Hugues, A Scholer, A Boissonnas, A Nussbaum, C Combadiere, S Amigorena, L Fetler
Nature immunology, 2007nature.com
Naive T lymphocytes move efficiently in lymphoid tissues while scanning dendritic cells in
search of cognate complexes of peptide in major histocompatibility molecules. However, T
cell migration ceases after recognition of cognate antigen. We show here that during the
initiation of antigen-specific CD8+ T cell responses, naive CD8+ polyclonal T cells'
preferentially'interacted in an antigen-independent way with mature dendritic cells
competent to present antigen to antigen-specific CD8+ T cells. These antigen-independent …
Abstract
Naive T lymphocytes move efficiently in lymphoid tissues while scanning dendritic cells in search of cognate complexes of peptide in major histocompatibility molecules. However, T cell migration ceases after recognition of cognate antigen. We show here that during the initiation of antigen-specific CD8+ T cell responses, naive CD8+ polyclonal T cells 'preferentially' interacted in an antigen-independent way with mature dendritic cells competent to present antigen to antigen-specific CD8+ T cells. These antigen-independent interactions required expression of the chemokine receptor CCR5 on polyclonal T cells and increased the efficiency of the induction of naive, low-precursor-frequency CD8+ T cell responses. Thus, antigen-specific CD8+ T cells favor the priming of naive CD8+ T cells by promoting the CCR5-dependent recruitment of polyclonal CD8+ T cells to mature dendritic cells.
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