Foxp3+ regulatory T cells in the control of experimental CNS autoimmune disease
RA O'Connor, SM Anderton - Journal of neuroimmunology, 2008 - Elsevier
The role of T regulatory (Treg) cells expressing the forkhead box transcription factor 3
(foxp3) in the control of autoaggressive immune responses is the subject of intense
investigation. Here we explore the contribution of these cells to the regulation of
experimental autoimmune encephalomyelitis (EAE). Starting from a historical perspective,
we review their roles in preventing spontaneous disease, in setting the threshold for
activation of a pathogenic response and in critically mediating the natural recovery from …
(foxp3) in the control of autoaggressive immune responses is the subject of intense
investigation. Here we explore the contribution of these cells to the regulation of
experimental autoimmune encephalomyelitis (EAE). Starting from a historical perspective,
we review their roles in preventing spontaneous disease, in setting the threshold for
activation of a pathogenic response and in critically mediating the natural recovery from …