[HTML][HTML] Identification of human macrophage inflammatory proteins 1α and 1β as a native secreted heterodimer
E Guan, J Wang, MA Norcross - Journal of Biological Chemistry, 2001 - ASBMB
Chemokines are secreted proteins that function as chemoattractants for leukocytes. The
chemokines macrophage inflammatory protein 1α and 1β (MIP-1α and MIP-1β) now have
been shown to be secreted from activated human monocytes and peripheral blood
lymphocytes (PBLs) as a heterodimer. Immunoprecipitation and immunoblot analysis
revealed that antibodies to either MIP-1α or MIP-1β precipitated a protein complex
containing both MIP-1α and MIP-1β under normal conditions from culture supernatants and …
chemokines macrophage inflammatory protein 1α and 1β (MIP-1α and MIP-1β) now have
been shown to be secreted from activated human monocytes and peripheral blood
lymphocytes (PBLs) as a heterodimer. Immunoprecipitation and immunoblot analysis
revealed that antibodies to either MIP-1α or MIP-1β precipitated a protein complex
containing both MIP-1α and MIP-1β under normal conditions from culture supernatants and …