Chemokine receptors are G-protein-coupled, seven-transmembrane-spanning surface
receptors that play key roles in cell trafficking, cell motility, and survival. These receptors are
activated by small molecular weight chemotactic cytokines called chemokines. Chemokine
receptors and their corresponding chemokine ligands play roles in the migration and
localization of normal T cells (and other cells) during physiological responses in inflamed or
infected skin. In psoriasis, the chemokine receptor CCR6 is expressed on the Th17 cells and …