Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort
BACKGROUND: GATA3 activates transcription of the TH2 cytokines, including IL13, an
important step in the allergic inflammatory pathway. OBJECTIVE: We sought to identify
associations of single nucleotide polymorphisms of the genes GATA3 and IL13 and their
interactions with rhinitis and allergic sensitization during childhood. METHODS: We
performed genetic association studies in a cohort of children (n= 923) who have been
evaluated for the development of rhinitis and allergic sensitization by means of skin prick …
important step in the allergic inflammatory pathway. OBJECTIVE: We sought to identify
associations of single nucleotide polymorphisms of the genes GATA3 and IL13 and their
interactions with rhinitis and allergic sensitization during childhood. METHODS: We
performed genetic association studies in a cohort of children (n= 923) who have been
evaluated for the development of rhinitis and allergic sensitization by means of skin prick …