[HTML][HTML] Enforced expression of the GATA-3 transcription factor affects cell fate decisions in hematopoiesis
D Chen, G Zhang - Experimental hematology, 2001 - Elsevier
OBJECTIVE: Three GATA family transcription factors are involved in various aspects of
hematopoiesis. Their lineage-restricted expression correlates well with their function in
selective lineage commitment and differentiation. We focused on the role of GATA-3 to
determine whether an intrinsic variation among different GATA proteins, in addition to the
distinct expression pattern, determines lineage specification. MATERIALS AND METHODS:
Using a retroviral vector, we introduced the GATA-3 gene into primary murine hematopoietic …
hematopoiesis. Their lineage-restricted expression correlates well with their function in
selective lineage commitment and differentiation. We focused on the role of GATA-3 to
determine whether an intrinsic variation among different GATA proteins, in addition to the
distinct expression pattern, determines lineage specification. MATERIALS AND METHODS:
Using a retroviral vector, we introduced the GATA-3 gene into primary murine hematopoietic …