Dichloroacetate modulates the oxidative stress and inflammatory response to exercise in COPD
EM Mercken, LD Calvert, SJ Singh, GJ Hageman… - Chest, 2009 - Elsevier
Background Impaired skeletal muscle function contributes to exercise intolerance in patients
with COPD. Exercise-induced oxidative stress may initiate or accelerate impaired muscle
function. Dichloroacetate (DCA) activates muscle pyruvate dehydrogenase complex (PDC)
at rest, reducing inertia in mitochondrial energy delivery at the onset of exercise and thereby
diminishing anaerobic energy production. This study aimed to determine whether DCA
infusion also may reduce exercise-induced systemic oxidative stress and inflammatory …
with COPD. Exercise-induced oxidative stress may initiate or accelerate impaired muscle
function. Dichloroacetate (DCA) activates muscle pyruvate dehydrogenase complex (PDC)
at rest, reducing inertia in mitochondrial energy delivery at the onset of exercise and thereby
diminishing anaerobic energy production. This study aimed to determine whether DCA
infusion also may reduce exercise-induced systemic oxidative stress and inflammatory …