Objective Altered subendothelial matrix composition regulates endothelial dysfunction and
early atherosclerotic plaque formation. Hyperglycemia promotes endothelial matrix
remodeling associated with multiple microvascular complications of diabetes, but a role for
altered matrix composition in diabetic atherogenesis has not been described. Therefore, we
sought to characterize the alterations in matrix composition during diabetic atherogenesis
using both in vitro and in vivo model systems. Methods and results Streptozotocin-induced …