[HTML][HTML] Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and …
EJ Weinman, D Steplock, S Shenolikar… - Journal of Biological …, 2011 - ASBMB
Fibroblast growth factor-23 (FGF-23) inhibits sodium-dependent phosphate transport in
brush border membrane vesicles derived from hormone-treated kidney slices of the mouse
and in mouse proximal tubule cells by processes involving mitogen-activated protein kinase
(MAPK) but not protein kinase A (PKA) or protein kinase C (PKC). By contrast, phosphate
transport in brush border membrane vesicles and proximal tubule cells from sodium-
hydrogen exchanger regulatory factor-1 (NHERF-1)-null mice were resistant to the inhibitory …
brush border membrane vesicles derived from hormone-treated kidney slices of the mouse
and in mouse proximal tubule cells by processes involving mitogen-activated protein kinase
(MAPK) but not protein kinase A (PKA) or protein kinase C (PKC). By contrast, phosphate
transport in brush border membrane vesicles and proximal tubule cells from sodium-
hydrogen exchanger regulatory factor-1 (NHERF-1)-null mice were resistant to the inhibitory …