Regulation of lymphocyte adhesion and migration by the small GTPase Rap1 and its effector molecule, RAPL
T Kinashi, K Katagiri - Immunology letters, 2004 - Elsevier
Dynamic regulation of integrin-mediated adhesion is central to lymphocyte trafficking and
antigen recognition. The small GTPase Rap1 is a potent stimulator of leukocyte integrins
through modulation of affinity and avidity. In addition, lymphocyte Rap1 has unique abilities
to trigger cell polarization and enhance cell motility. These characteristics of Rap1 contribute
to adhesive interactions with antigen-presenting cells (APC) and the vascular endothelium.
In the process of elucidating the molecular mechanisms of Rap1-mediated integrin …
antigen recognition. The small GTPase Rap1 is a potent stimulator of leukocyte integrins
through modulation of affinity and avidity. In addition, lymphocyte Rap1 has unique abilities
to trigger cell polarization and enhance cell motility. These characteristics of Rap1 contribute
to adhesive interactions with antigen-presenting cells (APC) and the vascular endothelium.
In the process of elucidating the molecular mechanisms of Rap1-mediated integrin …