BLT humanized mice as a small animal model of HIV infection
ME Karpel, CL Boutwell, TM Allen - Current opinion in virology, 2015 - Elsevier
Highlights•BLT humanized mice are valuable models for the study of HIV infection.•BLT mice
recapitulate important aspects of human immunity, including T cell immunity.•Various
limitations in the model continue to exist.•Recent approaches have improved engraftment
and human immunity in the model.Humanized mice are valuable models for the research
and development of vaccine strategies and therapeutic interventions to control or eradicate
HIV. The BLT humanized mouse model is particularly promising because the combination of …
recapitulate important aspects of human immunity, including T cell immunity.•Various
limitations in the model continue to exist.•Recent approaches have improved engraftment
and human immunity in the model.Humanized mice are valuable models for the research
and development of vaccine strategies and therapeutic interventions to control or eradicate
HIV. The BLT humanized mouse model is particularly promising because the combination of …