[HTML][HTML] IL-2 receptor γ-chain molecule is critical for intestinal T-cell reconstitution in humanized mice
PW Denton, T Nochi, A Lim, JF Krisko… - Mucosal …, 2012 - Elsevier
Intestinal immune cells are important in host defense, yet the determinants for human
lymphoid homeostasis in the intestines are poorly understood. In contrast, lymphoid
homeostasis has been studied extensively in mice, where the requirement for a functional
common γ-chain molecule has been established. We hypothesized that humanized mice
could offer insights into human intestinal lymphoid homeostasis if generated in a strain with
an intact mouse common γ-chain molecule. To address this hypothesis, we used three …
lymphoid homeostasis in the intestines are poorly understood. In contrast, lymphoid
homeostasis has been studied extensively in mice, where the requirement for a functional
common γ-chain molecule has been established. We hypothesized that humanized mice
could offer insights into human intestinal lymphoid homeostasis if generated in a strain with
an intact mouse common γ-chain molecule. To address this hypothesis, we used three …