CD81 protein is expressed at high levels in normal germinal center B cells and in subtypes of human lymphomas
CD81 is a tetraspanin cell surface protein that regulates CD19 expression in B lymphocytes
and enables hepatitis C virus infection of human cells. Immunohistologic analysis in normal
hematopoietic tissue showed strong staining for CD81 in normal germinal center B cells, a
cell type in which its increased expression has not been previously recognized. High-
dimensional flow cytometry analysis of normal hematopoietic tissue confirmed that among B-
and T-cell subsets, germinal center B cells showed the highest level of CD81 expression. In …
and enables hepatitis C virus infection of human cells. Immunohistologic analysis in normal
hematopoietic tissue showed strong staining for CD81 in normal germinal center B cells, a
cell type in which its increased expression has not been previously recognized. High-
dimensional flow cytometry analysis of normal hematopoietic tissue confirmed that among B-
and T-cell subsets, germinal center B cells showed the highest level of CD81 expression. In …