Adaptor proteins and ubiquinators in TGF-β signaling
L Mishra, B Marshall - Cytokine & growth factor reviews, 2006 - Elsevier
The emergence of research analyzing the TGF-β signaling pathway and its role in stem cell
plasticity and differentiation has been a source of new insights into multiple cancers. TGF-β
signaling mediator Smads are tightly dependent on modulation by adaptor proteins, such as
ELF, SARA, filamin, and crkl as well as ubiquitinators, such as PRAJA and SMURFs. Despite
widespread inactivation of the TGF-β pathway in gastrointestinal tumors, only a fraction of
sporadic tumors exhibit inactivating mutations in early tumor formation, which suggests a …
plasticity and differentiation has been a source of new insights into multiple cancers. TGF-β
signaling mediator Smads are tightly dependent on modulation by adaptor proteins, such as
ELF, SARA, filamin, and crkl as well as ubiquitinators, such as PRAJA and SMURFs. Despite
widespread inactivation of the TGF-β pathway in gastrointestinal tumors, only a fraction of
sporadic tumors exhibit inactivating mutations in early tumor formation, which suggests a …