Enhancer elements are the principal means through which cell type/contextspecific gene expression is achieved. Enhancers contain binding sites for multiple transcription factors that work in concert to regulate the activity of specific gene promoters. Enhancers can be separated from the genes that they regulate by large genomic distances, but are brought into close physical proximity through a process known as chromosome looping. The mechanisms through which chromosome looping between enhancers and promoters is regulated are incompletely understood. However, several reports have described widespread transcription occurring within enhancer elements and have suggested that the resulting noncoding RNA transcripts may be involved in enhancer-promoter interactions [1-5]. In a recent paper published in Cell