Revving the Throttle on an oncogene: CDK8 takes the driver seat
R Firestein, WC Hahn - Cancer research, 2009 - AACR
R Firestein, WC Hahn
Cancer research, 2009•AACRThe Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon
cancers. Prior work has provided important insights into the regulation of β-catenin stability
in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin
activates gene transcription in the nucleus. Using genetic approaches, studies in human
colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that
regulates β-catenin transcriptional activity. These convergent observations provide new …
cancers. Prior work has provided important insights into the regulation of β-catenin stability
in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin
activates gene transcription in the nucleus. Using genetic approaches, studies in human
colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that
regulates β-catenin transcriptional activity. These convergent observations provide new …
Abstract
The Wnt/β-catenin pathway plays an important role in initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of β-catenin stability in the cytoplasm; however, relatively little is known about the mechanism by which β-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regulates β-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear β-catenin activity and identify a novel therapeutic target for β-catenin-driven malignancies. [Cancer Res 2009;69(20):OF7899–901]
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