ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
Activation of extracellular signal-regulated kinase (ERK), a mitogen activated-protein kinase
(MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent
and-independent means. We have now investigated if ERK is activated in the spinal cord
after a spinal nerve ligation (SNL) and if this contributes to the neuropathic pain-like
behavior generated in this model. An L5 SNL induces an immediate (< 10min) but transient
(< 6h) induction of phosphoERK (pERK) restricted to neurons in the superficial dorsal horn …
(MAPK), in dorsal horn neurons contributes to inflammatory pain by transcription-dependent
and-independent means. We have now investigated if ERK is activated in the spinal cord
after a spinal nerve ligation (SNL) and if this contributes to the neuropathic pain-like
behavior generated in this model. An L5 SNL induces an immediate (< 10min) but transient
(< 6h) induction of phosphoERK (pERK) restricted to neurons in the superficial dorsal horn …