[HTML][HTML] Evidence that spinal astrocytes but not microglia contribute to the pathogenesis of Paclitaxel-induced painful neuropathy
H Zhang, SY Yoon, H Zhang, PM Dougherty - The Journal of Pain, 2012 - Elsevier
Paclitaxel often induces persistent painful neuropathy as its most common treatment-limiting
side effect. Little is known concerning the underlying mechanisms. Given the prominent role
of glial cells in many types of neuropathic pain, we investigated here the morphological and
functional changes of spinal astrocytes and microglia in a rat model of paclitaxel-induced
neuropathy. Immunohistochemistry, western blotting, and real-time polymerase chain
reaction were performed with samples from 109 rats up to 28 days after paclitaxel treatment …
side effect. Little is known concerning the underlying mechanisms. Given the prominent role
of glial cells in many types of neuropathic pain, we investigated here the morphological and
functional changes of spinal astrocytes and microglia in a rat model of paclitaxel-induced
neuropathy. Immunohistochemistry, western blotting, and real-time polymerase chain
reaction were performed with samples from 109 rats up to 28 days after paclitaxel treatment …