Intracerebral expression of CXCL13 and BAFF is accompanied by formation of lymphoid follicle-like structures in the meninges of mice with relapsing experimental …
R Magliozzi, S Columba-Cabezas, B Serafini… - Journal of …, 2004 - Elsevier
Given the abnormalities in B-cell activity occurring in the central nervous system (CNS) of
patients with multiple sclerosis (MS), we have explored the possibility that CNS inflammation
induced in mouse models of experimental autoimmune encephalomyelitis (EAE) triggers
expression of molecules that control the development and functional organization of
lymphoid follicles, the sites where B-cell responses are initiated. By reverse transcription–
polymerase chain reaction (RT-PCR), we find that gene expression of CXCL13, a …
patients with multiple sclerosis (MS), we have explored the possibility that CNS inflammation
induced in mouse models of experimental autoimmune encephalomyelitis (EAE) triggers
expression of molecules that control the development and functional organization of
lymphoid follicles, the sites where B-cell responses are initiated. By reverse transcription–
polymerase chain reaction (RT-PCR), we find that gene expression of CXCL13, a …