[HTML][HTML] Concerted activation of ETS protein ER81 by p160 coactivators, the acetyltransferase p300 and the receptor tyrosine kinase HER2/Neu
A Goel, R Janknecht - Journal of Biological Chemistry, 2004 - ASBMB
Activator of thyroid and retinoic acid receptor (ACTR) is overexpressed in∼ 60% of primary
human breast tumors and belongs to the p160 steroid receptor coactivator family. In this
study, we identified a novel interaction partner of ACTR, the ETS transcription factor ER81
that is also heavily implicated in mammary tumor formation. ACTR and related p160 family
members (steroid receptor coactivator-1 and glucocorticoid receptor-interacting protein-1
(GRIP-1)) augment ER81-mediated transcription. Although ACTR and GRIP-1 can acetylate …
human breast tumors and belongs to the p160 steroid receptor coactivator family. In this
study, we identified a novel interaction partner of ACTR, the ETS transcription factor ER81
that is also heavily implicated in mammary tumor formation. ACTR and related p160 family
members (steroid receptor coactivator-1 and glucocorticoid receptor-interacting protein-1
(GRIP-1)) augment ER81-mediated transcription. Although ACTR and GRIP-1 can acetylate …