High expression of the Met receptor in prostate cancer metastasis to bone

BS Knudsen, GA Gmyrek, J Inra, DS Scherr… - Urology, 2002 - Elsevier
OBJECTIVES: Expression of the active Met receptor tyrosine kinase causes tumor
metastasis in animal models. To begin to analyze whether Met expression might be related
to the spread of prostate cancer cells, we investigated whether its expression correlates with
prostate-specific antigen recurrence and whether its expression depends on the site of
metastasis. METHODS: Ninety radical prostatectomy specimens with a Gleason sum of 6 or
7 and 86 specimens of bone, lymph node, and soft-tissue metastasis were …