[HTML][HTML] Peripheral inflammation is associated with altered substantia nigra activity and psychomotor slowing in humans
L Brydon, NA Harrison, C Walker, A Steptoe… - Biological …, 2008 - Elsevier
BACKGROUND: Systemic infections commonly cause sickness symptoms including
psychomotor retardation. Inflammatory cytokines released during the innate immune
response are implicated in the communication of peripheral inflammatory signals to the
brain. METHODS: We used functional magnetic resonance brain imaging (fMRI) to
investigate neural effects of peripheral inflammation following typhoid vaccination in 16
healthy men, using a double-blind, randomized, crossover-controlled design. RESULTS …
psychomotor retardation. Inflammatory cytokines released during the innate immune
response are implicated in the communication of peripheral inflammatory signals to the
brain. METHODS: We used functional magnetic resonance brain imaging (fMRI) to
investigate neural effects of peripheral inflammation following typhoid vaccination in 16
healthy men, using a double-blind, randomized, crossover-controlled design. RESULTS …