Toll-like receptor regulation of intestinal development and inflammation in the pathogenesis of necrotizing enterocolitis

P Lu, CP Sodhi, DJ Hackam - Pathophysiology, 2014 - Elsevier
Toll-like receptors (TLRs) are a structurally related family of molecules that respond to a
wide variety of endogenous and exogenous ligands, and which serve as important
components of the innate immune system. While TLRs have established roles in host
defense, these molecules have also been shown to play important roles in the development
of various disease states. A particularly important example of the role of TLRs in disease
induction includes necrotizing enterocolitis (NEC), which is the most common …