Immune tolerance

M Akdis, AC Akdis - Middleton's allergy: principles and practice, 2013 - books.google.com
• B regulatory (Breg) cells play important roles in allergen tolerance with allergen-specific
suppression, expression of many suppressive molecules, and secretion of suppressive
cytokines, such as IL-10.• Breg cells increase in allergentolerance conditions such as
allergen-specific immunotherapy and high-dose allergen exposure, as in beekeepers.• In
allergic disease, the balance between allergen-specific Treg cells and disease-promoting T
helper 2 (Th2) cells appears to determine whether an “allergic” versus a “healthy” immune …

[BOOK][B] Immune Tolerance

DJ Mathis, AY Rudensky - 2013 - cshperspectives.cshlp.org
Immune Tolerance Organisms invoke a variety of immunologic mechanisms to effectively
eliminate or sequester infectious agents or reduce their load. Immune responses against
infectious agents elicit inflammation to facilitate their elimination and to restore tissue
homeostasis. Yet the benefits of resistance to pathogens are constrained by temporal or
lasting immune-mediated impairment in host function. Therefore, implicit in the resistance
strategy are numerous mechanisms of negative regulation of immune-mediated …