[HTML][HTML] Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production
AC Tosello-Trampont, SG Landes, V Nguyen… - Journal of Biological …, 2012 - ASBMB
Nonalcoholic steatohepatitis (NASH), characterized by lipid deposits within hepatocytes
(steatosis), is associated with hepatic injury and inflammation and leads to the development
of fibrosis, cirrhosis, and hepatocarcinoma. However, the pathogenic mechanism of NASH is
not well understood. To determine the role of distinct innate myeloid subsets in the
development of NASH, we examined the contribution of liver resident macrophages (ie
Kupffer cells) and blood-derived monocytes in triggering liver inflammation and hepatic …
(steatosis), is associated with hepatic injury and inflammation and leads to the development
of fibrosis, cirrhosis, and hepatocarcinoma. However, the pathogenic mechanism of NASH is
not well understood. To determine the role of distinct innate myeloid subsets in the
development of NASH, we examined the contribution of liver resident macrophages (ie
Kupffer cells) and blood-derived monocytes in triggering liver inflammation and hepatic …