[HTML][HTML] NF-κB is important for TNF-α-induced lipolysis in human adipocytes
L Jurga, AN Elisabet, D Andrea, B Lennart, N Erik… - Journal of lipid …, 2007 - ASBMB
Tumor necrosis factor-α (TNF-α) promotes lipolysis in mammal adipocytes via the mitogen-
activated protein kinase (MAPK) family, resulting in reduced expression/function of perilipin
(PLIN). The role of another pivotal intracellular messenger activated by TNF-α, nuclear factor-
κB (NF-κB), has not been recognized. We explored the role of NF-κB in TNF-α-induced
lipolysis of human fat cells. Primary cultures of human adipocytes were incubated in the
presence of a cell-permeable peptide that inhibits NF-κB signaling (WP). Incubation with …
activated protein kinase (MAPK) family, resulting in reduced expression/function of perilipin
(PLIN). The role of another pivotal intracellular messenger activated by TNF-α, nuclear factor-
κB (NF-κB), has not been recognized. We explored the role of NF-κB in TNF-α-induced
lipolysis of human fat cells. Primary cultures of human adipocytes were incubated in the
presence of a cell-permeable peptide that inhibits NF-κB signaling (WP). Incubation with …