What is the cause of the ageing atrophy?: Total number, size and proportion of different fiber types studied in whole vastus lateralis muscle from 15-to 83-year-old men

J Lexell, CC Taylor, M Sjöström - Journal of the neurological sciences, 1988 - Elsevier
In order to study the effects of increasing age on the human skeletal muscle, cross-sections
(15 μm) of autopsied whole vastus lateralis muscle from 43 previously physically healthy
men between 15 and 83 years of age were prepared and examined. The data obtained on
muscle area, total number, size, proportion and distribution of type 1 (slow-twitch) and type 2
(fast-twitch) fibers were analysed using multivariate regression. The results show that the
ageing atrophy of this muscle begins around 25 years of age and thereafter accelerates …