[HTML][HTML] Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase
J Feng, M Ito, K Ichikawa, N Isaka, M Nishikawa… - Journal of Biological …, 1999 - ASBMB
It is clear from several studies that myosin phosphatase (MP) can be inhibited via a pathway
that involves RhoA. However, the mechanism of inhibition is not established. These studies
were carried out to test the hypothesis that Rho-kinase (Rho-associated kinase) via
phosphorylation of the myosin phosphatase target subunit 1 (MYPT1) inhibited MP activity
and to identify relevant sites of phosphorylation. Phosphorylation by Rho-kinase inhibited
MP activity and this reflected a decrease in V max. Activity of MP with different substrates …
that involves RhoA. However, the mechanism of inhibition is not established. These studies
were carried out to test the hypothesis that Rho-kinase (Rho-associated kinase) via
phosphorylation of the myosin phosphatase target subunit 1 (MYPT1) inhibited MP activity
and to identify relevant sites of phosphorylation. Phosphorylation by Rho-kinase inhibited
MP activity and this reflected a decrease in V max. Activity of MP with different substrates …