Multiple proto-oncogene activations in avian leukosis virus-induced lymphomas: evidence for stage-specific events

BE Clurman, WS Hayward - Molecular and cellular biology, 1989 - Taylor & Francis
BE Clurman, WS Hayward
Molecular and cellular biology, 1989Taylor & Francis
We have examined avian leukosis virus-induced B-cell lymphomas for multiple, stage-
specific oncogene activations. Three targets for viral integration were identified: c-myb, c-
myc, and a newly identified locus termed c-bic. The c-myb and c-myc genes were associated
with different lymphoma phenotypes. The c-bic locus was a target for integration in one class
of lymphomas, usually in conjunction with c-myc activation. The data indicate that c-myc and
c-bic may act synergistically during lymphomagenesis and that c-bic is involved in late …
We have examined avian leukosis virus-induced B-cell lymphomas for multiple, stage-specific oncogene activations. Three targets for viral integration were identified: c-myb, c-myc, and a newly identified locus termed c-bic. The c-myb and c-myc genes were associated with different lymphoma phenotypes. The c-bic locus was a target for integration in one class of lymphomas, usually in conjunction with c-myc activation. The data indicate that c-myc and c-bic may act synergistically during lymphomagenesis and that c-bic is involved in late stages of tumor progression.
Taylor & Francis Online