The insulin receptor substrate-1: a biomarker for cancer?

R Baserga - Experimental cell research, 2009 - Elsevier
R Baserga
Experimental cell research, 2009Elsevier
This review focuses on IRS-1 and the evidence of its role in cell transformation. The
literature strongly suggests that IRS-1 should be considered a biomaker for cancers
susceptible to IGF-IR targeting. In addition, I would like to propose that IRS-1 may have a
more general role in cancer, and could be considered as a protein having the opposite effect
of tumor suppressors, a sort of anti-p53 molecule.
This review focuses on IRS-1 and the evidence of its role in cell transformation. The literature strongly suggests that IRS-1 should be considered a biomaker for cancers susceptible to IGF-IR targeting. In addition, I would like to propose that IRS-1 may have a more general role in cancer, and could be considered as a protein having the opposite effect of tumor suppressors, a sort of anti-p53 molecule.
Elsevier