A mathematical perspective on CD4+ T cell quorum-sensing
We analyse a mathematical model of the peripheral CD4+ T cell population, based on a
quorum-sensing mechanism, by which an optimum number of regulatory T cells can be
established and maintained. We divide the population of a single T cell receptor specificity
into four pools: naive, IL-2 producing, IL-2 non-producing, and regulatory CD4+ T cells.
Proliferation, death and differentiation of cells are introduced as transition probabilities of a
stochastic Markov model, with the assumption that the amount of IL-2 available to CD4+ T …
quorum-sensing mechanism, by which an optimum number of regulatory T cells can be
established and maintained. We divide the population of a single T cell receptor specificity
into four pools: naive, IL-2 producing, IL-2 non-producing, and regulatory CD4+ T cells.
Proliferation, death and differentiation of cells are introduced as transition probabilities of a
stochastic Markov model, with the assumption that the amount of IL-2 available to CD4+ T …