[HTML][HTML] Olfactory ensheathing cells as putative host cells for Streptococcus pneumoniae: evidence of bacterial invasion via mannose receptor-mediated endocytosis
H Macedo-Ramos, FSO Campos, LA Carvalho… - Neuroscience …, 2011 - Elsevier
Olfactory ensheathing cells (OECs) are a special glia that ensheath olfactory receptor axons
that enter the brain via olfactory phila, thus, providing a potential route for access of
pathogens. Streptococcus pneumoniae (Sp), that has a capsule rich in mannosyl residues,
is the most common cause of rhinosinusitis that may evolve to meningitis. We have tested
whether OECs in vitro express the mannose receptor (MR), and could internalize Sp via MR.
Cultures were infected by a suspension of Sp (ATCC 49619), recognized by an anti-Sp …
that enter the brain via olfactory phila, thus, providing a potential route for access of
pathogens. Streptococcus pneumoniae (Sp), that has a capsule rich in mannosyl residues,
is the most common cause of rhinosinusitis that may evolve to meningitis. We have tested
whether OECs in vitro express the mannose receptor (MR), and could internalize Sp via MR.
Cultures were infected by a suspension of Sp (ATCC 49619), recognized by an anti-Sp …