[HTML][HTML] Fatty acids modulate Toll-like receptor 4 activation through regulation of receptor dimerization and recruitment into lipid rafts in a reactive oxygen species …
SW Wong, MJ Kwon, AMK Choi, HP Kim… - Journal of Biological …, 2009 - ASBMB
The saturated fatty acids acylated on Lipid A of lipopolysaccharide (LPS) or bacterial
lipoproteins play critical roles in ligand recognition and receptor activation for Toll-like
Receptor 4 (TLR4) and TLR2. The results from our previous studies demonstrated that
saturated and polyunsaturated fatty acids reciprocally modulate the activation of TLR4.
However, the underlying mechanism has not been understood. Here, we report for the first
time that the saturated fatty acid lauric acid induced dimerization and recruitment of TLR4 …
lipoproteins play critical roles in ligand recognition and receptor activation for Toll-like
Receptor 4 (TLR4) and TLR2. The results from our previous studies demonstrated that
saturated and polyunsaturated fatty acids reciprocally modulate the activation of TLR4.
However, the underlying mechanism has not been understood. Here, we report for the first
time that the saturated fatty acid lauric acid induced dimerization and recruitment of TLR4 …