High-density lipoprotein inhibits the oxidative modification of low-density lipoprotein
S Parthasarathy, J Barnett, LG Fong - … et Biophysica Acta (BBA)-Lipids and …, 1990 - Elsevier
Oxidatively modified low-density lipoprotein (LDL), generated as a result of incubation of
LDL with specific cells (eg, endothelial cells, EC) or redox metals like copper, has been
suggested to be an atherogenic form of LDL. Epidemiological evidence suggests that higher
concentrations of plasma high-density lipoprotein (HDL) are protective against the disease.
The effect of HDL on the generation of the oxidatively modified LDL is described in the
current study. Incubation of HDL with endothelial cells, or with copper, produced much lower …
LDL with specific cells (eg, endothelial cells, EC) or redox metals like copper, has been
suggested to be an atherogenic form of LDL. Epidemiological evidence suggests that higher
concentrations of plasma high-density lipoprotein (HDL) are protective against the disease.
The effect of HDL on the generation of the oxidatively modified LDL is described in the
current study. Incubation of HDL with endothelial cells, or with copper, produced much lower …