Hybrid liposomes affect cellular lipid constituents and caveolae structures
K Cao, K Tanaka, Y Komizu, K Tamiya-Koizumi… - Bioorganic & medicinal …, 2012 - Elsevier
K Cao, K Tanaka, Y Komizu, K Tamiya-Koizumi, T Murate, R Ueoka, M Kyogashima…
Bioorganic & medicinal chemistry letters, 2012•ElsevierWe examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer
cells. As early as 1h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin,
ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the
cytoplasmic surface of the cell membrane were significantly changed. Our results suggest
that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.
cells. As early as 1h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin,
ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the
cytoplasmic surface of the cell membrane were significantly changed. Our results suggest
that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.
We examined alterations of lipid constituents induced by hybrid liposomes (HLs) in cancer cells. As early as 1h after HL treatment, amounts of the raft/caveolae lipids sphingomyelin, ceramide, and ether-type PC were altered. In addition, the structures of caveolae on the cytoplasmic surface of the cell membrane were significantly changed. Our results suggest that alterations of lipid composition in caveolae mediate HL signaling for apoptosis.
Elsevier