[HTML][HTML] Regulation of primary cilia formation by ceramide [S]
G Wang, K Krishnamurthy, E Bieberich - Journal of lipid research, 2009 - ASBMB
The primary cilium is an important sensory organelle, the regulation of which is not fully
understood. We found that in polarized Madin-Darby Canine Kidney cells, the sphingolipid
ceramide is specifically distributed to a cis-Golgi compartment at the base of the primary
cilium. This compartment immunostained for the centrosome marker γ-tubulin, the Rho type
GTPase cell division cycle 42 (Cdc42), and atypical protein kinase Cζ/λ (aPKC), a kinase
activated by ceramide and associated with a polarity protein complex consisting of …
understood. We found that in polarized Madin-Darby Canine Kidney cells, the sphingolipid
ceramide is specifically distributed to a cis-Golgi compartment at the base of the primary
cilium. This compartment immunostained for the centrosome marker γ-tubulin, the Rho type
GTPase cell division cycle 42 (Cdc42), and atypical protein kinase Cζ/λ (aPKC), a kinase
activated by ceramide and associated with a polarity protein complex consisting of …