Interleukin-12 (IL-12) has an essential role in the interaction between the innate and
adaptive arms of immunity by regulating inflammatory responses, innate resistance to
infection, and adaptive immunity. Endogenous IL-12 is required for resistance to many
pathogens and to transplantable and chemically induced tumors. In experimental tumor
models, recombinant IL-12 treatment has a dramatic anti-tumor effect on transplantable
tumors, on chemically induced tumors, and in tumors arising spontaneously in genetically …